Pozzi Dr. Edoardo, Belladelli Dr. Federico, Cilio Dr. Simone, Fallara Dr. Giuseppe, Corsini Dr. Christian, Lanzaro Dr. Francesco, Bertini Dr. Alessandro, Raffo Dr. Massimiliano, Negri Fausto, Cella Ludovica, Fantin Margherita, Candela Dr. Luigi, Capogrosso Dr. Paolo, Boeri Dr. Luca, d'Arma Dr. Alessia, Montorsi Prof. Francesco, Salonia Prof. Andrea

(100) PREVALENCE AND CLINICAL PROFILE OF VERY YOUNG MEN WITH ERECTILE DYSFUNCTION – FINDINGS FROM A REAL-LIFE CROSS-SECTIONAL STUDY

  • Urology
  • Reproductive Medicine
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Psychiatry and Mental health
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Abstract Objectives To assess and compare the sociodemographic and clinical characteristics of young (30-40 yr) and very young (18-29 yr) ED patients and to explore the changes in patterns of reported ED in men with ≤ 29 yr over a 17-yr period at a single academic centre. Methods Data from 519 consecutive patients < 40 yr complaining of ED between 2005 and 2022 were analysed. All patients completed the International IIEF. Patients were segregated into two groups: 18-29 vs. 30-40 yr. Descriptive statistics tested sociodemographic and clinical differences between the two cohorts. Linear regression and local polynomial models were applied to explore and graphically display the trend of assessing 18-29 vs. 30-40-yr ED patients over the analysed time-frame. Results Overall, 191 (36.8%) were < 29 yr and 328 (63.2%) were 30-40 yr. The two groups did not differ in terms of commonly recognised ED risk factors. Rates of severe ED according to IIEF-EF did not differ between the two cohorts at presentation (20.9% vs. 18.6%). Younger patients were less likely to report a stable partner (45.5% vs. 61.6%, p<0.001), to suffer of arterial hypertension (3.7% vs. 8.5%) and had lower median BMI (22.8 vs. 24.5 kg/m2) but higher total testosterone (5.6 vs. 5.1 ng/mL), all p<0.05 respectively. At linear regression analysis, patients assessed throughout the 17-yr time frame were progressively younger (Coeff –0.09, p<0.001). Figure 1 graphically displays the probability of assessing younger patients over the 17-yr time-frame with median (IQR) age in 2005 of 34 (32-34) yr vs. 29 (25-32) yr in 2022. Conclusions Among young men seeking first medical help for new onset ED, one out of three has less than 29 yr. Of those, one out of five reports criteria suggestive of severe ED. The probability of assessing very young men complaining of ED (18-29 yr) has worrisomely increased over the last two decades roughly. Conflicts of Interest N/A

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