Pozzi Dr. Edoardo, Fallara Dr. Giuseppe, Belladelli Dr. Federico, Cilio Dr. Simone, Corsini Dr. Christian, Lanzaro Dr. Francesco, Negri Fausto, Cella Ludovica, Fantin Margherita, Candela Dr. Luigi, Capogrosso Dr. Paolo, Boeri Dr. Luca, d'Arma Dr. Alessia, Montorsi Prof. Francesco, Salonia Prof. Andrea

(127) CLINICAL CHARACTERISTICS AT PRESENTATION OF PEYRONIE’S DISEASE PATIENTS HAVE CHANGED OVER THE LAST 20 YEARS

  • Urology
  • Reproductive Medicine
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Psychiatry and Mental health
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Abstract Objectives To detail and explore the changes of clinical and sociodemographic characteristics of a cohort of PD patients over a 17-yr period at a single referral centre. Methods Data from 616 consecutive patients complaining of PD as their primary complaint between 2005 and 2022 were analysed. Health significant comorbidities were scored with the CCI. All patients completed the IIEF at baseline. Descriptive statistics was used to detail the entire cohort characteristics. Linear regression models were applied to explore the changes in patterns of sociodemographic and clinical characteristics over a 17-yr period (2005-2022). Loess curve was used to graphically display the association between age at first clinical visit and year of assessment. Results Overall, the median (IQR) age and IIEF-EF were 56 (45-63) yr and 22 (10-28) respectively. Of all, 232 (37.7%) patients reported associated erectile dysfunction (ED) with 89 (14.4%) depicting criteria of severe ED (IIEF-EF <11). A CCI≥1 was found in 145 (23.5%); 193 (31.3%) patients had arterial hypertension and 72 (11.7%) had diabetes mellitus type 1 and 2. Overall, 115 (18.7%) had less than 40 yr at first presentation and 124 (20.1%) were active smokers. Over the analysed timeframe, at linear regression analysis, patients were more likely to be younger (Coeff -0.03, p<0.001), to report less comorbidities according to the CCI (Coeff -0.38, p<0.02), to have associated ED (Coeff. 1.21, p=0.002), to smoke more (Coeff 2.88, p<0.001) and to exercise more (Coeff 1.3, p<0.001). Figure 1 graphically displays the decreasing median age at first assessment over the 17-yr time-span with median (IQR) age in 2005 of 64 (59-69) yr vs. 51 (29-56) yr in 2022. Conflicts of Interest N/A Conclusions The probability of assessing younger PD patients has gradually increased over the last 20 years. In this context, one out of five patients seeking first medical help for PD is younger than 40 years of age.

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