Bingjun Zhou, Meilin Xian, Lu Ye, Weiyang Tang, Jian‐Liang Zhou

1,2‐Dioxetane‐based Chemiluminescence Probes for Tumor Optical Molecular Imaging

  • General Chemistry
Save to CiteDrive Show PDF

Abstract1,2‐Dioxetane‐based chemiluminescent probes have recently emerged as a promising tool for imaging biological systems, including disease diagnosis, staging, therapeutic response monitoring and surgical guidance. The advantages of these probes, such as high sensitivity and specificity and real‐time imaging capabilities, are based on their ability to generate chemiluminescent signals without the need for additional excitation sources, enzymes or oxidants after being triggered by target biomarkers under physiological conditions. Over the past decade, numerous 1,2‐dioxetane‐based chemiluminescent probes have been developed and tested for tumor imaging. In this review, we first introduce the trigger mechanism and structural improvements of these probes, followed by an overview of the design principles and applications of 1,2‐dioxetane‐based chemiluminescent probes in in vrtio and in vivo tumour imaging. In addition, the challenges and potential prospects of this technology in the field of bioanalysis and diagnostics are discussed, with the aim of stimulating further progress in the development of new chemiluminescence methods.

Need a simple solution for managing your BibTeX entries? Explore CiteDrive!

  • Web-based, modern reference management
  • Collaborate and share with fellow researchers
  • Integration with Overleaf
  • Comprehensive BibTeX/BibLaTeX support
  • Save articles and websites directly from your browser
  • Search for new articles from a database of tens of millions of references
Try out CiteDrive

More from our Archive