[2+2+1+1] Cycloaddition for de novo Synthesis of Densely Functionalized Phenols

doi:10.1002/anie.202307251

Wei Wei, Ka Key Cheung, Ran Lin, Lam Cheung Kong, Ka Lok Chan, Herman H. Y. Sung, Ian D. Williams, Rongbiao Tong, Zhenyang Lin, Guochen Jia

[2+2+1+1] Cycloaddition for de novo Synthesis of Densely Functionalized Phenols

General Chemistry
Catalysis

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AbstractA unique benzannulation strategy for regioselective de novo synthesis of densely functionalized phenols is described. Through metal‐mediated formal [2+2+1+1] cycloaddition of two different alkynes and two molecules of CO, a series of densely functionalized phenols were obtained. The benzannulation strategy allows efficient regioselective installation up to five different substituents on a phenol ring. The resulting phenols have a substitution pattern different from those obtained from Dötz and Danheiser benzannulations.

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[2+2+1+1] Cycloaddition for de novo Synthesis of Densely Functionalized Phenols

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