Curvo Dr. Raphael, Fernandez-Pascual Dr. Esaú, Manfredi Celeste, Martín Dr. Cristina, Martinez-Ballesteros Dr. Claudio, Balmori Dr. Carlos, Lledó-García Dr. Enrique, Quintana Dr. Luis Miguel, Carballido Prof. Joaquin Alberto, Bianco Jr Dr. Fernando, Martinez-Salamanca Juan Ignacio

(246) SEXUAL FUNCTION RESULTS AFTER FOCAL CRYOTHERAPY FOR THE TREATMENT OF LOCALIZED PROSTATE CANCER

  • Urology
  • Reproductive Medicine
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Psychiatry and Mental health
Save to CiteDrive Show PDF

Abstract Objectives To assess the sexual functional results in patients with primary localized PC treated with FC guided by MRI/US fusion. Methods Prospective, monocentric study with patients with localized and primary PCa, low or intermediate risk, with unifocal or multifocal lesions, PSA ≤ 15 ng/mL, undergoing FC. The main variables studied were the International Index of Erectile Function-Erectile Function domain (IIEF-EF) and the ejaculatory function. The follow-up included evaluation before treatment, at 6 months and at 12 months. Recurrence was defined as the presence of clinically significant PCa in the treated areas. Other functional outcomes were assessed (continence, lower urinary tract symptoms). Results A total of 75 patients were recruited. The median age was 67 (62-72) years. Pretreatment PSA and IIEF-EF were 6.56ng/ml (IQR 5.1-8) and 17 (IQR 7-22), respectively. The volume of the lesions was 1cc (IQR 0.5-2.5), the majority (76%) were peripheral and the Gleason-Score was 6 in 44%, 7 (3+4) in 26.7% and 7 (4+ 3) in 22.7%. Ten subjects developed a recurrence (RR: 15.2%), with a median follow-up of 25 (18-38) months. At 12 months, we found a statistically significant difference (p<0.001) in the IIEF-EF (17 (7-22) VS. 16.5 (8-20)), although not clinically significant. In addition, 15/69 (21.7%) subjects had started or increased the dose of PDE5i. Before treatment, 7 patients had ejaculatory disorders (alpha-blockers). At 12 months, there were 8 affected patients. No significant differences (p>0.05) were observed in urinary functional results (IPSS, ICIQ-UI), all patients were continents at one year. Conclusions FC in selected patients with localized PCa is an option to consider in patients who wish to preserve sexual function and who assume a low, although not negligible, recurrence rate. Conflicts of Interest None

Need a simple solution for managing your BibTeX entries? Explore CiteDrive!

  • Web-based, modern reference management
  • Collaborate and share with fellow researchers
  • Integration with Overleaf
  • Comprehensive BibTeX/BibLaTeX support
  • Save articles and websites directly from your browser
  • Search for new articles from a database of tens of millions of references
Try out CiteDrive

More from our Archive