Vena Dr. Walter, Bianchi Dr. Nicola, Frizza Dr. Francesca, Briganti Dr. Francesca, Rastrelli Prof. Giulia, Vignozzi Prof. Linda, Barbonetti Prof. Arcangelo, Pizzocaro Dr. Alessandro, Brunetti Dr. Alessandro, Mannucci Prof. Edoardo, Sforza Dr. Alessandra, Maggi Prof. Mario, Corona Dr. Giovanni

(279) THE ROLE OF TESTOSTERONE TREATMENT IN PATIENTS WITH METABOLIC SYNDROME: RESULTS FROM A META-ANALYSIS STUDY

  • Urology
  • Reproductive Medicine
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Psychiatry and Mental health
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Abstract Objectives Metabolic syndrome (MetS) is often associated with male hypogonadism. Despite the well-known link, the role of testosterone [T] replacement therapy [TRT] on glycometabolic profile and body composition, in patients with metabolic syndrome [MetS], is still conflicting and argue of large scientific debate. The aim of the present study is to meta-analyze the role of TRT in MetS considering all placebo and non-placebo-controlled randomized clinical trials [RCTs]. Methods An extensive Medline search was performed including the following words “testosterone”, “metabolic syndrome” and “males”. No search software was used, but we hand-searched bibliographies of retrieved papers for additional references. Results Overall, 7 studies were available including 576 patients with a mean follow-up of 48.9 weeks. These trials differ in basal TT levels and type of T preparation used. In addition, only 6 were placebo controlled. TRT resulted to significantly improve waist circumferece, fasting glycemia, A1c serum levels, HOMA-Indes and serum tryglycerides (p < 0.001) when all studies were considered, however this difference was not significant when only placebo-controlled studies were considered, except for waist circumference (p= 0.05). When only placebo/controlled RCT were considered, TRT resulted to significantly improve body fat mass (p= 0.04). Conclusions TRT was able to significantly decrease fasting glycaemia, glycosylated hemoglobin, HOMA-IR index, triglyceride levels, fat mass and waist circumference. In contrast, we did not observe any significant effect on total or HDL cholesterol, blood pressure and BMI. When considering only placebo-controlled studies, only differences of HbA1c, HOMA-IR index, triglyceride levels, fat mass and waist circumference retained statistical significance, but not fasting glycaemia, although a trend was apparent. Conflicts of Interest No conflict of interest to declare.

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