Engel Dr. Jannis, Sinke Dr. Christopher, Veit Maria, Kneer Dr. Jonas, Hartmann Prof. Uwe, Krüger Prof. Tillmann H

(61) UNLEASHED DESIRE: IS THERE ALTERED RESTING STATE FUNCTIONAL CONNECTIVITY IN MEN WITH COMPULSIVE SEXUAL BEHAVIOR DISORDER?

  • Urology
  • Reproductive Medicine
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Psychiatry and Mental health
Save to CiteDrive Show PDF

Abstract Objectives Problems arising from compulsive sexual behavior disorder (CSBD) are often seen in clinical settings. In the sex@brain study we aimed to extend the knowledge about the clinical characteristics and the underlying neurobiology of individuals with CSBD. Methods We used a seed-based resting state fMRI approach investigating state functional connectivity in CSBD. A group of men with CSBD (n = 39) was compared to a group of healthy controls (n = 33). Groups were matched for age and educational level. The focus of this investigation lies on frontal and limbic regions highly relevant for emotional processing and behavioral control. Results Initial results showed increased connectivity between the left amygdala and left Precuneus/superior parietal cortex as well decreased connectivity between the right middle OFC and gyrus rectus in men with CSBD compared to healthy controls. Moreover, attenuated connectivity between putamen and anterior cingulate cortex was found in men with CSBD when compared to healthy controls. Conclusions The results highlight the importance of a strong functional connectivity between limbic regions and areas involved in attention. In addition, a diminished connectivity between parts of the reward system and areas involved in sexual inhibition was observed. These results, however, should to be interpreted with caution, as different studies in the field show very divergent results. Further research is needed for the understanding of the interplay between emotional and behavioral control and may contribute to a better understanding of sexual compulsive behavior and may lead to more differentiated and effective diagnostics and treatment. Conflicts of Interest none

Need a simple solution for managing your BibTeX entries? Explore CiteDrive!

  • Web-based, modern reference management
  • Collaborate and share with fellow researchers
  • Integration with Overleaf
  • Comprehensive BibTeX/BibLaTeX support
  • Save articles and websites directly from your browser
  • Search for new articles from a database of tens of millions of references
Try out CiteDrive

More from our Archive