A biomarker framework for auditory system aging: the Aging Biomarker Consortium consensus statement
, Xiaolong Fu, Si Wang, Yunhao Wu, Yu Sun, Wenwen Liu, Xin Xi, Genglin Li, Ke Liu, Wei Yuan, Fangyi Chen, Hongyang Wang, Tao Yang, Yuhe Liu, Jialin Zheng, Haibo Shi, Jing Qu, Xiaowei Chen, Limin Suo, Yideng Huang, Xinbo Xu, Xuxia Tang, Xiaojun Li, Lei Xu, Xia Gao, Lisheng Yu, Yilai Shu, Weiqi Zhang, Jinpeng Sun, Huijun Yuan, Shusheng Gong, Wenyan Li, Xiulan Ma, Dingjun Zha, Jiangang Gao, Huawei Li, Zuhong He, Guang-Hui Liu, Gang Pei, Weijia Kong, Haibo Wang, Renjie ChaiAbstract
Hearing is one of the most vital sensory functions in human beings and a crucial means of perceiving and acquiring information from the natural environment. The advancement of human society is closely linked to the development of language, with hearing serving as the foundation for verbal communication. As individuals age, the deterioration of the auditory system becomes a significant factor contributing to sensory impairments in the elderly. In addition to hearing loss, the aging of the auditory system is also associated with cognitive decline and psychosocial disorders, which severely impact the quality of life for older adults. Currently, there are no effective treatments or interventions available for addressing the aging of the auditory system. Therefore, identifying biomarkers of the auditory system aging is of great significance. The Aging Biomarker Consortium of China has conducted a comprehensive evaluation of aging biomarkers in the auditory system, focusing on three dimensions: morphological, functional, and humoral biomarkers. This initiative aims to establish a foundation for assessing the degree of aging in the auditory system and to promote the management of auditory health in an aging society, ultimately enhancing the auditory health of the elderly population both in China and globally