Gastrointestinal stromal tumor (GISTs) are rare mesenchymal neoplasms of the alimentary tract accounts for 0.1 -3% . GISTs arise from interstitial cells of cajal and most commonly occurs in stomach. They are best identied by computed tomography (CT) scan and most stain positive for CD117 (C-Kit), CD34, and/or DOG-1. Aim And Objective: The aim of the case series to analyze epidemiological aspects, clinical presentation , challenges in diagnosis , management of the diseases. A case series of 3 patients with GIST admitt Materials And Methods; ed in the DEPARTMENT OF GENERAL SURGERY IN GOVERNMENT KILPAUK MEDICAL COLLEGE AND GOVERNMENT ROYAPETTAH HOSPITAL ,CHENNAI .All 3 cases have been analyzed in this study period and followed up until discharged from the hospital Results: Out of three patient one patient landed up in emergency ward with obstructive features and intervened by emergency procedure, second patient presented with unusual presentation and treated by surgery with chemotherapy , and other patient presented with symptoms and treated by surgery and followed by chemotherapy. GISTs are r Conclusion: elatively rare tumor of gastrointestinal tract. Hence a higher degree of suspicion is essential for identifying GISTs clinically. Earlier identication will help in better management. This case series shows 3 possible clinical presentations of GIST.

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