DOI: 10.1039/d3cb00044c ISSN:
A covalent inhibitor of the YAP–TEAD transcriptional complex identified by high-throughput screening
Kayla Nutsch, Lirui Song, Emily Chen, Mitchell Hull, Arnab K. Chatterjee, Jian Jeffery Chen, Michael J. Bollong- Biochemistry, Genetics and Molecular Biology (miscellaneous)
- Molecular Biology
- Biochemistry
- Chemistry (miscellaneous)
A pyrazolopyrimidine-based inhibitor covalently targets the four TEAD paralogs, inhibiting YAP dependent cell growth and transcription.