Cheng Chen, Yinsui Xu, Peter Oelschlaeger, Jürgen Brem, Lu Liu, Dongmei Wang, Hongzhe Sun, Ke-Wu Yang

A dual covalent binder for labelling and inhibiting serine and metallo-carbapenemases

  • Materials Chemistry
  • Metals and Alloys
  • Surfaces, Coatings and Films
  • General Chemistry
  • Ceramics and Composites
  • Electronic, Optical and Magnetic Materials
  • Catalysis

The novel SeCN-based covalent warhead, DS01, DS02 and DC01 was reported to inhibit and label the serine and metallo-carbapenemases, with IC50 values range of 0.0038–1.27 μg mL−1, by forming covalent bonds with Cys221 of NDM-1 and Ser70 of KPC-2.

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