Yesenia Mancera‐Hurtado, Blanca E. Lopez‐Contreras, Regina Flores‐Lopez, Hugo Villamil‐Ramirez, Blanca E. del Rio‐Navarro, Samuel Canizales‐Quinteros, Sofia Moran‐Ramos

A dysregulated bile acids pool is associated with metabolic syndrome and gut microbial dysbiosis in early adolescence

  • Nutrition and Dietetics
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Medicine (miscellaneous)
Save to CiteDrive Show PDF

AbstractObjectiveThe increased prevalence of childhood metabolic syndrome (MetS) is a public health issue. It has been shown that a dysregulated bile acid (BA) profile could be involved in the development of MetS, in which the gut microbiota could have a significant role in BA levels. This study aimed to evaluate differences in serum BA levels in children with and without MetS and whether these levels were associated with gut microbial composition.MethodsA total of 100 children aged 10 to 12 years were enrolled in this study, 42 children with MetS (cases) and 58 control participants. Serum BAs were measured by liquid chromatography‐tandem mass spectrometry and gut microbiota was determined by 16S ribosomal RNA gene sequencing.ResultsChildren with MetS showed higher levels of total, secondary, and 12α‐hydroxylated BAs, as well as deoxycholic acid, and these were associated with dyslipidemia and insulin resistance markers. Interestingly, total BAs were negatively correlated with gut bacterial diversity (Shannon index: rho = −0.218, p = 0.035), whereas total, 12α‐hydroxylated, and secondary BAs, as well as deoxycholic acid, showed negative correlations with genera known for their potential health effects, including Bifidobacterium, Akkermansia, and Faecalibacterium.ConclusionsThis study suggests that childhood MetS is associated with a dysregulated BA pool and that these alterations could influence the abundance of potentially beneficial bacteria, thus contributing to gut microbial dysbiosis.

Need a simple solution for managing your BibTeX entries? Explore CiteDrive!

  • Web-based, modern reference management
  • Collaborate and share with fellow researchers
  • Integration with Overleaf
  • Comprehensive BibTeX/BibLaTeX support
  • Save articles and websites directly from your browser
  • Search for new articles from a database of tens of millions of references
Try out CiteDrive

More from our Archive