AbstractDeveloping hemostatic agents with reliable biosafety and high efficiency has paramount clinical significance for saving lives. Herein, inspired from traditional Chinese medicine, a sponge (BC‐S) with hierarchical porous structure is proposed for the treatment of bleeding. The BC‐S is prepared by a simple self‐assembly method employing Bletilla Striata polysaccharide and quaternary amine alkaloids (QA) from Bletilla Striata and Coptidis Rhizoma. The ideal cation donor encapsulated in the helical structure of BSP enlarges the inter‐layer space of sponge by the action of electrostatic repulsion, forming wider channels which can accelerate the diversion speed of absorbed blood. Then, platelets and erythrocytes are trapped tightly in the reticular structure and extruded to deformation, activation. Subsequently, fibrin network forms and reinforces the internal multilayer mesh, blocks the outflow of blood. QA is released from the sponge skeleton mainly driven by a combination of surface erosion and potentially solution diffusion among pore to provide long‐term antibacterial activity. Benefiting from the well‐designed structure and the effective hemostatic mechanism, the BC‐S displays more excellent hemostatic performance in different models in vivo and in vitro compared with typical gelatin hemostatic sponge. This work is expected to boost the development of emerging hemostatic agents.

More from our Archive

• DOI: 10.3390/pharmaceutics15071916 2023

  Artificial Intelligence in Pharmaceutical Technology and Drug Delivery Design

  Lalitkumar K. Vora, Amol D. Gholap, Keshava Jetha, Raghu Raj Singh Thakur, Hetvi K. Solanki, Vivek P. Chavda

• DOI: 10.3390/ph16070934 2023

  A Scoping Review and Meta-Analysis of Anti-CGRP Monoclonal Antibodies: Predicting Response

  Ja Bin Hong, Kristin Sophie Lange, Lucas Hendrik Overeem, Paul Triller, Bianca Raffaelli, Uwe Reuter

• DOI: 10.3390/molecules28135145 2023

  Cancer Nanomedicine: Emerging Strategies and Therapeutic Potentials

  Manman Xu, Xinpu Han, Hongtai Xiong, Yijie Gao, Bowen Xu, Guanghui Zhu, Jie Li

• DOI: 10.3390/md21070384 2023

  Algal Phycocolloids: Bioactivities and Pharmaceutical Applications

  Silvia Lomartire, Ana M. M. Gonçalves

• DOI: 10.1002/ardp.202300097 2023

  Novel promising benzoxazole/benzothiazole‐derived immunomodulatory agents: Design, synthesis, anticancer evaluation, and in silico ADMET analysis

  Hazem Elkady, Khaled El‐Adl, Helmy Sakr, Adel S. Abdelraheem, Sally I. Eissa, Mohamed Ayman El‐Zahabi

• DOI: 10.3390/molecules28135282 2023

  Anti-α-Glucosidase, SAR Analysis, and Mechanism Investigation of Indolo[1,2-b]isoquinoline Derivatives

  Mengyue Li, Lin Li, Li Lu, Xuetao Xu, Jinhui Hu, Jin-Bao Peng

• DOI: 10.3390/pharmaceutics15071906 2023

  Comparison of Bovine- and Porcine-Derived Decellularized Biomaterials: Promising Platforms for Tissue Engineering Applications

  Hussein M. El-Husseiny, Eman A. Mady, Masahiro Kaneda, Kazumi Shimada, Yasumoto Nakazawa, Tatsuya Usui, Mohamed Elbadawy, Yusuke Ishihara, Moeko Hirose, Yohei Kamei, Ahmed S. Doghish, Hesham A. El-Mahdy, Walaa A. El-Dakroury, Ryou Tanaka

• DOI: 10.1002/adhm.202301010 2023

  Clinical Translation of Extracellular Vesicles

  Aayushi Ghodasara, Aun Raza, Joy Wolfram, Carlos Salomon, Amirali Popat

• DOI: 10.3390/molecules28135186 2023

  Homogeneous Electrochemical Aptamer Sensor Based on Two-Dimensional Nanocomposite Probe and Nanochannel Modified Electrode for Sensitive Detection of Carcinoembryonic Antigen

  Zhengzheng Yan, Shiyue Zhang, Jiyang Liu, Jun Xing

• DOI: 10.3390/molecules28145407 2023

  Recent Developments and Applications of Microbial Levan, A Versatile Polysaccharide-Based Biopolymer

  Marta Domżał-Kędzia, Monika Ostrowska, Agnieszka Lewińska, Marcin Łukaszewicz