Kinetochore-localized chromosomal passenger complex (CPC) is essential for chromosome bipolar attachment, but it moves to the spindle during anaphase. The reversal of CDK-dependent phosphorylation Sli15, a CPC subunit, has been shown to promote CPC translocation. Here, we found that reversal of Ipl1-dependent Sli15 phosphorylation by Fin1-PP1 also causes CPC translocation, thereby revealing a new layer of regulation for CPC translocation.

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