DOI: 10.1039/d3md00744h ISSN: 2632-8682
A novel BODIPY-based theranostic agent for in vivo fluorescence imaging of cerebral Aβ and ameliorating Aβ-associated disorders in Alzheimer's disease transgenic mice
Jingjing Zhang, Wenming Ren, Xiaohui Liu, Jingjing Chen, Yuteng Zeng, Huaijiang Xiang, Youhong Hu, Haiyan Zhang- Organic Chemistry
- Drug Discovery
- Pharmaceutical Science
- Pharmacology
- Molecular Medicine
- Biochemistry
We report the synthesis, characteristics, and biological evaluations of a novel theranostic agent, P14, for both in vitro and in vivo imaging of central Aβ plaques, inhibition of Aβ aggregation, and neuronal damage as well as behavioral deficits.