DOI: 10.1039/d3an01126g ISSN:
A novel design of DNA duplex containing programmable sensing sites for nanopore-based length-resolution reading and applications for Pb2+ and cfDNA analysis
Jiahai Wang, Cenlin Gui, Jianji Zhu, Baian Zhu, Zhuobin Zhu, Xiwen Jiang, Daqi Chen- Electrochemistry
- Spectroscopy
- Environmental Chemistry
- Biochemistry
- Analytical Chemistry
A novel design of dsDNA block contained a programmable sensing site inside is proposed, which can be programmed with different sequences to respond to multiple target molecules (e.g. Pb2+ and cfDNA) by being cleaved into two smaller DNA blocks.