A Novel Halogen‐Illumined Hydrazine Fluorescent Probe

Abstract

Hydrazine had important applications in medicine, the chemical industry, and agriculture, but hydrazine pollution was also very harmful to human beings. Chemists have reported many types of hydrazine fluorescent probes. However, it was still challenging to continuously improve the selectivity and sensitivity of hydrazine fluorescent probes. Here, we designed and synthesized a novel NH₂NH₂ fluorescent probe based on the neighboring group participation (NGP). We choose bromine and chlorine as the neighboring group respectively. The probe had good anti‐interference ability. The detection limits to hydrazine were 0.027 µM (probe A) and 0.054 µM (probe B). The sensing mechanism was confirmed by ¹H NMR, ¹³C NMR, and FT‐IR. Theoretical calculation showed that the energy barrier could be reduced by NGP. In terms of application, the probe has the function of quantitative detection of hydrazine in actual water samples.