Shobhini Baghel, Shefali Sharma, Surbhi Gupta

A PROSPECTIVE STUDY FOR THE PREDICTION OF PREECLAMPSIA WITH SERUM PROLACTIN LEVEL

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Introduction: Preeclampsia is a pregnancy-specic condition which is diagnosed based on the presence of the following clinical features: blood pressure (BP) ≥140/90 mmHg after 20 weeks of gestation and proteinuria ≥300 mg/24- hr or +1 with dipstic. Serum prolactin, being a vasoinhibin precursor molecule and it its anti-angiogenic activity may contribute to the pathophysiology of preeclampsia. So that Serum prolactin can be used as a new reliable parameter in early prediction of preeclampsia. Material and Methods: Prospective observational study carried out which included 139 pregnant women taken for study after pre-lling the inclusion and exclusion criteria, serum prolactin was done of every patient from 16-20 weeks then followed till delivery for the development of preeclampsia. The preeclampsia incidence was seen to be 12.24%(17 patients) Results: during the study duration. The mean serum prolactin levels were higher for the preeclampsia patients (382.41 vs 163.78) with a statistically signicant difference (P<0.001). The sensitivity and specicity of the prolactin levels at cut off of 302ng/ml was 94.12% and 90.16%. The PPV and NPV were 57.14% and 99.10%. Conclusion: Study concluded that there is an increased risk of development of Preeclampsia with an increased level of serum prolactin in early pregnancy. Early prediction of PE will offer a great potential to lower the rate of fetomaternal complications and provide a window for early intervention.

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