Chenling Lv, Zhenzhong Zhang, Yan Zhang, Lin Zhong, Ziqiang Yu, Dengjun Guo

A rare case report of Huntington’s disease with severe psychiatric symptoms as initial manifestations

  • Biological Psychiatry
  • Psychiatry and Mental health
  • Genetics (clinical)
  • Genetics
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Introduction Huntington’s disease (HD) stands as an inherited and progressive neurodegenerative ailment distinguished by chorea-esque movement patterns, which manifest as archetypal symptoms. The presence of pronounced psychiatric onset symptoms in patients can considerably amplify the intricacies of accurate diagnosis. Case presentation A 43-year-old gentleman was admitted with a five-year chronicle of delusions, hallucinations, and irritability. He had previously received a diagnosis of schizophrenia and had been subjected to a regimen of antipsychotic medications for a span exceeding four years. However, subsequent to the application of cerebral MRI and genetic testing, his condition was conclusively redetermined as HD. Conclusion The salient attribute of this case resides in the deferred diagnosis of HD attributable to the presence of acute psychiatric initial symptoms, a scenario bearing noteworthy ramifications for disease oversight and prognostication. This instance warrants attentive scrutiny and discourse within the professional community.

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