The rational use of antibiotics is essential to combat the growing threat of anti-microbial resistance, improve patient outcomes, and optimize healthcare resources. Effective antibiotic stewardship programs play a crucial role in guiding healthcare professionals and patients towards appropriate antibiotic use. These programs encompass a range of interventions, including education and training, clinical guidelines, antimicrobial stewardship teams, and surveillance systems. By implementing these strategies, healthcare facilities can enhance antibiotic prescribing practices, reduce unnecessary antibiotic use, and prevent the emergence and spread of antibiotic-resistant bacteria. Additionally, public awareness campaigns are vital in empowering individuals to understand the appropriate use of antibiotics, emphasizing the importance of completing prescribed courses, and discouraging self-medication. Promoting awareness among the general population helps mitigate misconceptions and misuse, ensuring antibiotics are used judiciously and only when necessary. Keywords: AMR (Anti-microbial resistance), Anti-microbial Stewardship, rational use, health care professionals.

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