A Simplified Protocol for Large-Scale Preparation of 4CzIPN and 3DPA2FBN
Yongda Zhang, Zhen Lei, Yibo Xu, Stephanie C. Kosnik, Qi Jiang- Organic Chemistry
Abstract
Just in the past few years, the application of 4CzIPN as a photocatalyst in photochemistry has been dramatically increased with its unique properties. In the literature, a variety of protocols for the synthesis of 4CzIPN have been reported. However, a practical process for the preparation of 4CzIPN with consistent quality on large scale is not available, but highly desirable to enable the robust application of this photocatalysis in industry. Herein, we detailed a practical and simple column-free chemical process amenable for the large-scale production of 4CzIPN with high quality in 91% yield. Current process was demonstrated on large scale. The similar process protocol was applicable and demonstrated for the synthesis of 3DPA2FBN on large scale.