Manoj Kumar Prajapati, Rajesh Kumar Rai, Shaila Kumari Mitra, Ankita Kumari, Chhavi bajpai, Sachin Karanwal

A STUDY OF HEMATOLOGICAL AND BIOCHEMICAL PARAMETERS IN ASSESSING SEVERITY IN COVID-19 PATIENTS

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Background: The severity of COVID-19 could be evaluated by examining several blood parameters mainly white blood cell (WBC) count, granulocytes, platelet, and novel hemocytometric markers neutrophils to lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR),lymphocyte to monocyte ratio (LMR) and biochemical parameters such as CRP,D-dimer, Serum ferritin, LFT, KFT etc. Methods and Material: The present study has been carried out on 100 RTPCR conrmed covid-19 patients over a period of one year from July 2021 to June 2022. Clinical features, investigations, and history of associated risk factors were extracted from case records. Samples were processed in Medonic M series ve part haematology analyzer. SELECTRA PRO M and ARCHITECT plus machine was used for LDH, AST, ALT, Creactive protein (CRP),Serum creatinine and serum urea. Samples for electrolytes were processed in INNOLYTE MACHINE. The sample for D-dimer and PT INR were processed in STA SETELLITE Max haemostasis analyser. Samples for procalciton in were processed in CARDIAMARKER HIA-1200 machine. Chi squre test was used for analyzing signicant correlation among different parameters and covid-19 severity. P value<0.05 was dened as statistically signicant for all statistical test. Statistical analysis used: Retrospective observational study Results: Among 100 RTPCR conrmed cases,40,36,20 and 4 were mild, moderate, severe and critical respectively. Total total neutrophils count signicantly raised in critical patients(p value<0.05) while absolute lymphocyte count was signicantly decreased in critical patients(p value<0.05).NLR was signicantly raised in critical patients and LMR,PLR were also signicantly related to disease severity. CRP, S. ferritin and Ddimer were signicantly raised in critical patients(p value<0.05).Besides above parameters, Serum LDH, Serum electrolytes, AST, AL, .PT-INR were also raised in critically ill patients(p value<0.05). Conclusions: The severity of COVID-19 can be identied at an early stage by following the different routine biochemical marker levels and subsequently improve prognosis.

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