Bora Dharitree, Umbon Jawgam, Borah Rajib Kr

“A STUDY ON CLINICOETIOLOGICAL PROFILE OF PATIENTS WITH UPPER GASTROINTESTINAL BLEEDING WITH SPECIAL REFERENCE TO HELICOBACTER PYLORI INFECTION.”

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Background: Acute gastrointestinal bleeding is one of the most life threatening gastrointestinal emergencies encountered in the medical eld. It remains a major cause of morbidity and mortality all over the world with a variable etiological prole. Hence, this study was undertaken with the aim to analyse the etiological and clinical prole of patients presenting with upper gastrointestinal bleeding and its association with H. Pylori from the region of North East India. This is a cross-sectional observational study, Methods: carried out in the Department of Medicine, at Jorhat Medical College and Hospital in North-east India. We enrolled patients from in-patient setting over a period of 1 year including a total of 120 subjects presenting with upper GI bleed. A detailed clinical history, physical examination and investigations were conducted in alongwith UGI endoscopy. Data was analysed by SPSS. We analysed 120 patients diagnosed with Upper Results: GI bleed (69.2% males, 30.8% females), Ratio of 2.4:1. The most common symptom was found to be melena with hematemesis, 51 patients( 42.5%), endoscopy nding showed that 40.8% patients had UGI bleed due to oesophageal and/ or gastric varcies, 29.1% patients had peptic ulcer disease, 16.6% patients had gastric/ duodenal erosions, 1.7% had MW Tear, 1.7% had gastric malignancy and 1 patient had both oesophageal varices and peptic ulcer disease. H. Pylori was an independent risk factor in both variceal and non-variceal bleed(p<0.003). This study concludes that varices Conclusion: due to portal hypertension is found to be the most common etiology of upper gastrointestinal bleeding, followed closely by peptic ulcer disease in the north east India. Melena with Hematemesis was found to be the most common presentation of these patients and infection with H. pylori acts an independent risk factor for both variceal and non-variceal bleeding.

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