AbstractIssuesConsideration of an individual's quality of life (QoL) can benefit assessment and treatment of addictive disorders, however, uncertainty remains over operationalisation of the construct as an outcome and the appropriateness of existing measures for these populations. This systematic review aimed to identify and evaluate QoL and health‐related QoL outcome instruments used in addiction‐related risk and harm research and map their conceptualised domains.ApproachThree electronic databases and a specialised assessment library were searched on 1 February 2022 for QoL or health‐related QoL outcome instruments used with addiction‐related risk and harm populations. PRISMA reporting guidance was followed and included outcome instruments were appraised using mixed methods. Psychometric evidence supporting their use was summarised. The COSMIN risk of bias tool was used to assess validation studies.Key FindingsA total of 298 articles (330 studies) used 53 outcome instruments and 41 unique domains of QoL. Eleven instruments' psychometric properties were evaluated. No instrument was assessed for any parameter in at least five studies for meta‐analytic pooling. Cronbach's alpha (α) internal consistency was the most widely assessed parameter with the AQoLS, WHOQOL‐BREF, ALQoL‐9, Q‐LES‐Q‐SF, SF‐12, DUQoL, QLI and SF‐36 displaying promising statistics (α > 0.70).Implications and ConclusionMany instruments have been utilised. However, a significant proportion of studies applied a small number of instruments with minimal high‐quality validation evidence supporting their use within addiction‐related risk and harm. Promising instruments are recommended, however, the paucity of supporting evidence limits confidence in the reliability and validity of QoL measurement in these populations.

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