Abstract 131: Association Between Left Ventricular Injury Detected by Cardiac MRI and Incident Ischemic Stroke: The Multi-Ethnic Study of Atherosclerosis
Richa Sharma, Spencer Hansen, Alexander E Merkler, Joao Lima, W T Longstreth- Advanced and Specialized Nursing
- Cardiology and Cardiovascular Medicine
- Neurology (clinical)
Background: The association between left ventricular injury (LVI) detected by cardiac magnetic resonance imaging (CMR) and the risk of a subsequent ischemic stroke is unknown.
Methods: We studied stroke-free participants in the Multi-Ethnic Study of Atherosclerosis study who underwent a steady-state free precession CMR at Exam 5 (2010-2012). The exposure of interest was LVI defined by either LV ejection fraction (EF) < 50% or circumferential strain
Results: The analytic sample consisted of 2,584 participants (n=302 or 11.7% with LVI, n=2,282 or 88.3% without LVI). There were a total of 18 ischemic stroke events among those with LVI (6%) and 65 among those without LVI (3%). Participants with LVI were significantly older, male, Black, had higher BMI, and lower HDL. Participants with LVI were more likely to have diabetes, tobacco use, and atrial fibrillation (24% versus 14%, p<0.001). There was no significant difference in history of cardiovascular disease events (6% versus 4%, p=0.143). LVI was significantly and independently associated with incident ischemic stroke (adjusted hazard ratio 1.80, 95% C.I. 1.04-3.12). When participants were stratified into 3 mutually exclusive groups of no LVI, LVEF
Conclusion: LVI identified by CMR is a significant, independent predictor of incident ischemic stroke. LV apical circumferential strain