Accuracy of Figure Memory Test of the Brief Cognitive Screening Battery to predict amyloid status in older adults with Subjective Cognitive Decline
Adalberto Studart Neto, Artur Martins Coutinho, Camila de Godoi Carneiro, Natália Cristina Moraes, Raphael Ribeiro Spera, Monica Sanches Yassuda, Sonia Maria Dozzi Brucki, Carlos Alberto Buchpiguel, Ricardo NitriniAbstract
Background
Some older adults with subjective decline (SCD) had a positive amyloid biomarker indicating a preclinical stage of Alzheimer’s disease.
Objectives
To assess the accuracy of Delayed Recall of Figure Memory Test (DR‐FMT) of Brief Cognitive Screening Battery to predict amyloid status in SCD older adults.
Method
The sample consisted of 45 older adults classified as SCD and 25 as cognitively unimpaired (mean age of 76.4 and 73.5, respectively, p = 0.138). They were evaluated with BCSB and a standard neuropsychological battery (which includes MMSE, MoCA, RAVLT, Logical Memory and DR of Rey Complex Figure). Subjects were underwent PIB‐PET to assess their amyloid status and images were classified based on visual and semi‐quantitative analyses with 3D‐SSP methodology.
Result
Twelve SCD older adults (27.3%) were positive amyloid against six in the controls (23.1%). In SCD group, DR‐FMT was the only memory test that correlated with SUV in amyloid PET (r = ‐0.514, p < 0.001). Only DR‐FMTshowed significant area under the curve (AUC) in the ROC curve in SCD older adults (AUC = 0.771, 95% CI 0.621 ‐ 0.921). Among SCD older adults, DR‐FMT < 8.0 had a sensitivity of 83.3%, a specificity of 68.7% and an accuracy of 72.7%.
Conclusion
FMT proved to have a good sensitivity and accuracy to predict amyloid status in SCD older adults.