DOI: 10.1039/d4ra01501k ISSN: 2046-2069

Activity against Mycobacterium tuberculosis of a new class of spirooxindolopyrrolidine embedded chromanone hybrid heterocycles

Manal Fahad Alkaltham, Abdulrahman I. Almansour, Natarajan Arumugam, Siva Krishna Vagolu, Tone Tønjum, Shatha Ibrahim Alaqeel, Saiswaroop Rajaratnam, Venketesh Sivaramakrishnan
  • General Chemical Engineering
  • General Chemistry

Spirooxindolopyrrolidines were synthesized in quantitative yield through cycloaddition strategy. Compounds exhibited significant anti-tubercular activity and molecular docking studies of the compound is well correlates with in vitro findings.

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