Felipe Mattioni Maturana, Rebecca Rolf, Simone Schweda, Max Reimer, Manuel Widmann, Christof Burgstahler, Andreas M. Nieß, Inga Krauss, Barbara Munz

Adipokines as Predictive Biomarkers for Training Adaptation in Subjects with Multimorbidity—A Hypothesis-Generating Study

  • General Medicine
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Background. Physical exercise exerts a positive effect on many chronic conditions, specifically lifestyle-related diseases such as overweight and obesity, type 2 diabetes mellitus (T2DM), cardiovascular conditions and osteoarthritis (OA). As a result of common risk factors, most of these patients present with multiple conditions. Exercise- and disease-related biomarkers, such as adipokines, are emerging tools in training supervision and regulation; however, their significance in subjects with multimorbidities is unknown. Subjects and Methods. To address this issue, adipokines leptin, adiponectin and resistin were assessed in a cohort of subjects with multimorbidities (n = 39) presenting with at least two of the abovementioned conditions or relevant risk factors before and after a six-month exercise and lifestyle intervention program (‘MultiPill-Exercise’), and correlated with training adaptation, namely changes in relative maximum oxygen uptake (V·O2max). Results. There was a significant negative correlation between baseline leptin concentrations and training effect for relative V·O2max (after three months: rho = −0.54, p = 0.020 *; after six months: rho = −0.45, p = 0.013 *), with baseline leptin explaining 35% of the variance in delta relative V·O2max after three months and 23% after six months. Conclusions. Leptin might be a suitable surrogate biomarker in the context of exercise-based lifestyle intervention programs in subjects with multimorbidity.

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