DOI: 10.1039/d3ra04590k ISSN:
Advanced Guareschi–Thorpe synthesis of pyridines in green buffer, and pH-controlled aqueous medium with ammonium carbonate
Fatemeh Tamaddon, Sajedeh Maddah-Roodan- General Chemical Engineering
- General Chemistry
Hydroxy-cyanopyridines are easily synthesized via an advanced version of the Guareschi–Thorpe reaction by three-component condensation of alkyl cyanoacetate or cyanoacetamide with 1,3-dicarbonyls and ammonium carbonate in aqueous medium.