DOI: 10.1039/d4sc00390j ISSN: 2041-6520
All-photonic kinase inhibitors: light-controlled release-and-report inhibition
Cassandra L. Fleming, Carlos Benitez-Martin, Elin Bernson, Yongjin Xu, Linnea Kristenson, Tord Inghardt, Thomas Lundbäck, Fredrik B. Thorén, Morten Grøtli, Joakim Andréasson- General Chemistry
An all-photonic method is described, in which (i) the release of an active kinase inhibitor is controlled externally with light; and (ii) fluorescence is employed to report both the release and binding of the inhibitor to its corresponding target.