Qian Wei, Lei Li, Xiaoqing Zeng, Jie Yin, Jinsheng Guo

An analysis on the clinical features and risk factors associated with the prognosis of patients with drug-induced liver injury

  • General Earth and Planetary Sciences
  • General Engineering
  • General Environmental Science
  • General Medicine
  • General Earth and Planetary Sciences
  • General Environmental Science
  • Materials Chemistry
  • Economics and Econometrics
  • Media Technology
  • Forestry
  • Pharmacology (medical)
  • Complementary and alternative medicine
  • Pharmaceutical Science
  • General Medicine
  • Immunology and Allergy
  • Applied Mathematics
  • General Mathematics
  • Pulmonary and Respiratory Medicine
  • Pediatrics, Perinatology, and Child Health
  • Microbiology
Save to CiteDrive Show PDF

Aim: This is a Chinese population-based study aimed to determine the causes and clinical features of drug-induced liver injury (DILI) from traditional Chinese medicines (TCMs) and current Western medicines (WMs) and identify the risk factors of drug-induced liver failure (DILF) and chronic DILI for early recognition and better management. Methods: The medical records of patients who were diagnosed with DILI for at least six-month follow-up between January 2018 to December 2020 were reviewed and investigated. The risk factors of DILF and chronic DILI were identified by univariate and multivariate logistic regression analysis. Results: TCMs (47.5%) including herbal medicine (83.0% in TCM-induced DILI) and some Chinese patent drugs were the leading cause of DILI in the present study. Cholestatic type was more associated with severe and chronic DILI. Pre-existing gallbladder disease, initial total bilirubin (TBIL), initial prothrombin time (PT), initial antinuclear antibodies (ANA), and clinical classification are independent risk factors for DILF. Prolonged T0.5AST and T0.5GGT were independent risk factors for chronic DILI [area under the curve (AUC) = 0.812, 95% confidence interval (CI): 0.748–0.876, P < 0.001] with cut-off values of 8.5 days and 29.5 days, respectively. Conclusions: TCMs especially herbal medicine were the leading causes of DILI, and the risk of developing severe DILI was associated with pre-existing gallbladder disease, clinical classification, initial TBIL, PT, and ANA. T0.5AST and T0.5GGT might serve as indicators for chronicity.

Need a simple solution for managing your BibTeX entries? Explore CiteDrive!

  • Web-based, modern reference management
  • Collaborate and share with fellow researchers
  • Integration with Overleaf
  • Comprehensive BibTeX/BibLaTeX support
  • Save articles and websites directly from your browser
  • Search for new articles from a database of tens of millions of references
Try out CiteDrive

More from our Archive