AbstractAn efficient procedure for the synthesis of novel spiro[indoline‐3,11′‐pyrazolo[3,4‐f]pyrimido[4,5‐b]quinoline] derivatives has been developed by one‐pot condensation of 1H‐indazol‐6‐amine, isatin and barbituric acid or 2‐thiobarbituric acid, in the presence of L‐proline in refluxing EtOH. This method has the advantages of operational simplicity, high yield of products via a simple experimental and work‐up procedure. IR, 1H NMR, 13C NMR, 19F NMR and HRMS were used to identify the structures of all the synthesized compounds.

More from our Archive

• DOI: 10.3390/gels9070523 2023

  Polymer-Based Hydrogels Applied in Drug Delivery: An Overview

  Nguyen Hoc Thang, Truong Bach Chien, Dang Xuan Cuong

• DOI: 10.3390/ijms241310846 2023

  Urinary MicroRNAs as Biomarkers of Urological Cancers: A Systematic Review

  Achille Aveta, Simone Cilio, Roberto Contieri, Gianluca Spena, Luigi Napolitano, Celeste Manfredi, Antonio Franco, Fabio Crocerossa, Clara Cerrato, Matteo Ferro, Francesco Del Giudice, Paolo Verze, Francesco Lasorsa, Andrea Salonia, Rajesh Nair, Jochen Walz, Giuseppe Lucarelli, Savio Domenico Pandolfo

• DOI: 10.3390/gels9070556 2023

  A Review of Patents and Innovative Biopolymer-Based Hydrogels

  Snežana Ilić-Stojanović, Ljubiša Nikolić, Suzana Cakić

• DOI: 10.3390/molecules28135145 2023

  Cancer Nanomedicine: Emerging Strategies and Therapeutic Potentials

  Manman Xu, Xinpu Han, Hongtai Xiong, Yijie Gao, Bowen Xu, Guanghui Zhu, Jie Li

• DOI: 10.3390/molecules28135282 2023

  Anti-α-Glucosidase, SAR Analysis, and Mechanism Investigation of Indolo[1,2-b]isoquinoline Derivatives

  Mengyue Li, Lin Li, Li Lu, Xuetao Xu, Jinhui Hu, Jin-Bao Peng

• DOI: 10.3390/molecules28135186 2023

  Homogeneous Electrochemical Aptamer Sensor Based on Two-Dimensional Nanocomposite Probe and Nanochannel Modified Electrode for Sensitive Detection of Carcinoembryonic Antigen

  Zhengzheng Yan, Shiyue Zhang, Jiyang Liu, Jun Xing

• DOI: 10.3390/molecules28145407 2023

  Recent Developments and Applications of Microbial Levan, A Versatile Polysaccharide-Based Biopolymer

  Marta Domżał-Kędzia, Monika Ostrowska, Agnieszka Lewińska, Marcin Łukaszewicz

• DOI: 10.1002/jhet.4705 2023

  Regioselective synthesis and computational calculation studies of some new pyrazolyl‐pyridine and bipyridine derivatives

  Ahmad M. Farag, Nabila A. Kheder, Asmaa M. Fahim, Kamal M. Dawood

• DOI: 10.3390/molecules28135024 2023

  Evaluation of Antimicrobial, Anticholinesterase Potential of Indole Derivatives and Unexpectedly Synthesized Novel Benzodiazine: Characterization, DFT and Hirshfeld Charge Analysis

  Abdul Rauf Raza, Syeda Laila Rubab, Muhammad Ashfaq, Yasir Altaf, Muhammad Nawaz Tahir, Muhammad Fayyaz ur Rehman, Tariq Aziz, Metab Alharbi, Abdullah F. Alasmari

• DOI: 10.3390/molecules28145428 2023

  Biomedical Applications of Zirconia-Based Nanomaterials: Challenges and Future Perspectives

  Azzah M. Bannunah