Archana Yadav, Pradeep Patil, Nagesh Birajdar, Anna Gophane, Krishna Chaitanya Gunturu, Shankar Hangirgekar, Sandeep Sankpal

An expeditious synthesis and histo–toxicological study of 1,2,3‐triazoles catalyzed by a novel Fe3O4@SiO2‐Pr‐Thiosemicarbazide‐Cu(II) as a magnetically separable catalyst

  • Inorganic Chemistry
  • General Chemistry
Save to CiteDrive Show PDF

A novel Fe3O4@SiO2‐Pr‐Thiosemicarbazide‐Cu(II) as a magnetically separable catalyst was synthesized and further confirmed by FT‐IR, TGA, XRD, FE‐SEM, EDX, ICP‐AES, TEM, VSM, and XPS analyses. The catalytic efficiency of Fe3O4@SiO2‐Pr‐Thiosemicarbazide‐Cu(II) was examined in the one‐pot environmentally friendly synthesis of 1,2,3‐triazoles by reacting terminal alkynes, alkyl halides, and sodium azide in ethanol at 55°C. The results revealed Fe3O4@SiO2‐Pr‐Thiosemicarbazide‐Cu(II) nano–sizedcatalyst is advantageous in terms of excellent activity, high stability, and easily recoverable in the synthesis of 1,2,3‐triazoles. The mechanistic study of Fe3O4@SiO2‐Pr‐Thiosemicarbazide‐Cu(II) catalyzed synthesis of 1,2,3‐triazole is also supported by DFT calculations. The significant advantages of this catalytic system are mild reaction conditions, easy work‐up procedure, magnetic separation, heterogeneity, an excellent yield of the product, and recyclability without a notable decrease of catalytic potency for six runs. Further, histotoxicological assessment of synthesized 1,2,3‐triazoles was done on the Indian major carpLabeo rohita.

Need a simple solution for managing your BibTeX entries? Explore CiteDrive!

  • Web-based, modern reference management
  • Collaborate and share with fellow researchers
  • Integration with Overleaf
  • Comprehensive BibTeX/BibLaTeX support
  • Save articles and websites directly from your browser
  • Search for new articles from a database of tens of millions of references
Try out CiteDrive

More from our Archive