DOI: 10.2174/0115701786336830241118160207 ISSN: 1570-1786
An Improved and Practical Approach to the Synthesis of Terbinafine as an Anti-Fungal Agent
V. Satteyyanaidu, P. Naveen Reddy, Srinivas Gajula, U. Poojitha, Ganesh Nalla, B. V. Subba ReddyAbstract:
An improved strategy for the synthesis of terbinafine has been developed through the crosscoupling of (E)-aminovinyl chloride with tert-butyl acetylene using 1 mol% of 5% Pd/C as a recyclable heterogeneous catalyst under mild conditions. This is the first report on the Pd/C catalyzed Sonogashira coupling to produce the 99.9% pure terbinafine under mild conditions.