Priyam Jain, Sumit Kumar Singh, Gunjan Kela

APPLICABILITY OF THE INTEGRATED NEONATAL CHOLESTASIS CARD AT A TERTIARY CARE CENTRE FROM INDIA

  • General Earth and Planetary Sciences
  • Water Science and Technology
  • Geography, Planning and Development
  • Social Sciences (miscellaneous)
  • Sociology and Political Science
  • Social Psychology
  • General Earth and Planetary Sciences
  • General Environmental Science
  • General Medicine
  • General Medicine
  • General Materials Science
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Objectives: Delay in detection of Neonatal Cholestasis (NC) results in late referral of treatable causes of NC hampering the timely intervention. To overcome this by early detection of NC, an integrated NC card incorporating urine color was developed in India recently. This study was aimed to assess the applicability of integrated NC card. An analytical cross-sectional study was carried out at a tertiary care institute over Methods: a period of 18 months. Study participants were divided into 3 groups. Group A: infants with cholestasis, Group B: infants with unconjugated hyperbilirubinemia and Group C: healthy infants visiting the immunization clinic. Real-time stool and urine color of all study participants were assessed using integrated NC card by care-takers (mother) and the study investigator separately and documented for comparative analysis. A total of 130 subjects (Group A: 30; Group B: 50; Results: Group C: 50). were enrolled in study. The median age of children with in group A was 45 (28-125 days), Group B was 6 (2-50) days and Group C was 85 (40-185) days. Measure of agreement between investigator and care-takers: For dark yellow urine in group A: 93%, kappa=0.634; for normal urine in group B and C: 96%, Kappa= 0.648 and 98%, kappa=0.847 respectively. For pale stool in group A: 85%, kappa=0.550; for normal stool in group B and C: 93%, kappa= 0.623 and 96%, kappa=0.730 respectively. The Conclusion: integrated NC card was found useful in detection of NC based on urine color and differentiate it from unconjugated hyperbilirubinemia

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