Qipeng Long, Xinchen Tian, Haochen Wang, Ni Zhang, Tao Han, Zhe Li, Shulong Jiang

Applications of DNA tetrahedron nanostructure in cancer diagnosis and anticancer drugs delivery

  • Surfaces, Coatings and Films
  • Process Chemistry and Technology
  • Energy Engineering and Power Technology
  • Biomaterials
  • Medicine (miscellaneous)
  • Biotechnology
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Abstract DNA nanostructures constructed under the guidance of DNA nanotechnology have developed rapidly for the last two decades, standing at the forefront in the biomedical field. Among them, DNA tetrahedron nanostructure (DTN) has emerged as one of the most representative DNA nanostructures. DTN was easily formed by one-step annealing of four single-stranded DNA. Due to its unique advantages such as simple and stable structural composition, high synthesis efficiency, uniform nanometer size, high programmability, and good biocompatibility, DTN has been widely used in biological detection, biological imaging, drug delivery, and other fields, and shows a great potential. Especially in the detection of cancer-related biomarkers and the delivery of anticancer drugs, nano-platforms based on DTN has achieved great success. In this review, we focus on the applications of DTN in cancer diagnosis and therapy, as well as the challenges and prospects.

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