Assessing survival outcomes of patients with oral tongue squamous cell carcinoma: Focus on age, sex, and stage
Saagar Pamulapati, Marin Abousaud, Yixuan Li, Asari Ekpenyong, Soumon Rudra, Jill S. Remick, James E. Bates, William A. Stokes, Mark W. McDonald, Nicole C. Schmitt, Mark W. El‐Deiry, Mihir R. Patel, Conor E. Steuer, Jeffrey M. Switchenko, Dong M. Shin, Yong Teng, Anthea Hammond, Nabil F. SabaAbstract
Background
The purpose of this study was to provide further insights into whether age and/or sex are associated with prognosis in oral tongue squamous cell carcinoma.
Methods
This was a retrospective cohort study utilizing hospital registry data from 2006 to 2016 obtained from the National Cancer Database. Identified patients were divided into various cohorts based on age, sex, and staging. A descriptive analysis was performed using chi‐square tests and overall survival rates were estimated using Kaplan–Meier method.
Results
A total of 17 642 patients were included in the study. The 5‐year overall survival rates were 82.0% (95% CI: 79.8%–84.0%) in younger patients versus 67.5% (95% CI: 66.7%–68.3%, p‐value <0.0001) older patients. The median overall survival for females was 143.4 months (95% CI: 133.2–NA) versus 129.8 (95% CI: 125.4–138.7, p‐value <0.0001) in males.
Conclusions
Our analysis suggests that younger age and female sex are both predictors of improved survival in oral tongue squamous cell carcinoma.