Arsh Singh, Amit Gupta, Simran Srivastava, Bhavya Choudhury, Sidharth Jain, AB Bajpai

Assessment its Antioxidant, Antimicrobial and Anti-Inflammatory Potential of Momordica Charantia

  • Pharmacology
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Natural products are believed to be one of the richest sources of prophylactic and therapeutic-based compounds which show a wide range of applications in the food and pharmaceutical industries. An aqueous extract of Momordica charantia was evaluated systematically for antioxidant (2,2-diphenyl-1-picrylhydrazyl, DPPH free radical assay), antimicrobial (bacterial strains), and anti-inflammatory (heat-induced hemolysis, proteinase inhibitory activity, protein denaturation, i.e., bovine serum albumin, BSA, and typhoid vaccine) agents, as well as its phenolic content. The results showed its higher concentration of phenolic content, as reported in this study, which is directly correlated with the antioxidant activity of Momordica charantia against DPPH. Similar results were obtained in the antimicrobial assay, where the diameter of the inhibition zone against bacterial strains is measured in millimetres (mm), which is wider in the case of the aqueous extract. In addition, anti-inflammatory studies were also taken into consideration, and the results suggest that higher doses of Momordica charantia may enhanced the percentage of protein denaturation as compared to BSA or typhoid vaccine alone and also induced heat induce hemolysis and proteinase inhibitory activity, In short, Momordica charantia may have shown several immunopharmacological properties, and this study may have been used further have used for isolation of desired prophylactic or therapeutic based compounds and to develop better nutraceutical or pharmaceutical agents.

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