ASSESSMENT OF ROLE OF INDUCTION CHEMOTHERAPY IN MANAGEMENT OF LOCALLY ADVANCED SQUAMOUS CELL CARCINOMA OF ORAL CAVITY

Background:Head and neck cancer is a heterogeneous disease,consisting of several subsites with differing pathologic and molecular characteristics, causative factors, therapeutic response, and prognosis. Systemic treatment is typically used in the management of head and neck squamous cell carcinoma (HNSCC).Theoretically, induction chemotherapy (IC) reduces the risk of distant metastasis and enables in vivo testing of responses and tumor biology.Thus,the purpose of this study was to investigate the efficacy,toxicity, and impact of IC in locally advanced squamous cell carcinoma (LASCC) of the oral cavity.Methodology:This prospective observational clinical study was conducted from March 2014 to April 2016. In this study, a total of 50 patients were enrolled. Among them, routine laboratory investigations including complete blood cell tests, chest x-ray, electrocardiogram (ECG), and computed tomography (CT) scan were investigated. Results: In the present study, 50 patients were included between the ages between 40 to 50 years. The prevalence of HNSCC was mostly found in males,with a male-to-female ratio of 2.12.IC results in organ preservation for approximately 50% of patients. Furthermore, findings show that, only 25% of cases were experienced both local and regional recurrence. Conclusion: IC was found to be the most effective method for the diagnosis of HNSCC, as it was well tolerated with no negative impact on radiotherapy or surgery.