Rajesh Kumar Saini, Ashok Mosalpuri, Punit Gupta, Nitesh Kumar Sharma

ASSOCIATION BETWEEN PLATELET INDICES AND ACUTE CORONARY SYNDROMES IN A TERTIARY CARE CENTRE – A COMPARATIVE STUDY

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Introduction: Platelets plays important role in progression of atherosclerosis. Alpha granules and dense granules of platelet contains many chemokines, cytokines and growth factors. Release of these factors along with interaction with endothelial cells and leukocytes promotes inflammation and atherosclerosis. There is scope to make better use of the platelet parameters generated, as patients with larger platelets can easily be identified during routine hematological analysis and could possibly benefit from timely treatment. The study was undertaken to account the efficacy of platelet parameters in Acute Coronary Syndromes. The current study was a case control study carried Material And Methods: out in the Department of Medicine, SRGH Hospital, which is affiliated with Jhalawar Medical College, from February 2022 to December 2022. The purpose of this study was to comparison between the platelet indices in patients with ACS and those with non cardiac chest pain. Approval from Institutional Ethical Committee of the Hospital was taken before the start of the study. A total 200 participants were included among them 100 were cases diagnosed with ACS and 100 controls with those with non cardiac chest pain were included. Data were analyzed in SPSS v- 24. Independent t-test and Chi-square test were applied. Pearson correlation coefficient was calculated. p value <0.05 was considered statistically significant. In the present study, no statistically significant difference in platelets count and pl Observation: ateletcrit (%) were found between both groups. However, a statistically significant high PDW, MPV and P-LCR were found among the cases compare to the controls. In the current study, accuracy of PDW, MPV, P-LCR and plateletcrit to detect ACS was found to be 95.7%, 92.2%, 94.4% and 46.7% respectively. The current study's findings appear to CONCLUSIONS: confirm and substantiate that higher platelet indices such as mean platelet volume (MPV), platelet distribution width (PDW), and platelet large cell ratio (P-LCR) contribute to the prothrombotic state in Acute coronary syndrome (ACS), and that larger platelets may also play a specific role in ACS.

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