Background: Diabetes mellitus (DM) is a group of diseases characterized by high blood glucose levels resulting from a defect in the body's ability to produce and/or use insulin. It is believed that oxidative stress plays important role in the development of vascular complications in type 2 diabetes Objectives: to determine the serum concentrations of endogenous melatonin and superoxide dismutase(SOD) in cases of Type 2 DM and compare it with normal controls and to assess the correlation between melatonin and SOD. Materials and methods: A case control study was done on 70 patients with diabetes mellitus type 2 according to ADA definition of DM type 2 recruited from Al Imamain Al-Kathemeaain medical city, Baghdad, Iraq who compared with 70 age, BMI and gender matched healthy control group in the levels of serum melatonin, serum superoxide dismutase (SOD), fasting blood glucose (FBG) level, glycated hemoglobin (HbA1c), lipid profile, serum urea and serum creatinine. Results: the activities of SOD enzyme were significantly (p=0.037) lower than those of controls which is accompanied with a significant reduction in the melatonin levels in patients comparing with controls with a significant positive correlation between GPX activity and melatonin levels in both patients and control groups. Conclusions: melatonin levels showed to be reduced significantly in diabetic patient which may play an essential role in reducing the defense mechanism against ROS via affecting the activity of GPx enzyme.

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