Association of the neutrophil-to-lymphocyte ratio with the occurrence of venous thromboembolism and arterial thrombosis
Ha Thanh Nguyen, Minh Phuong Vu, Thi Tuyet Mai Nguyen, Tuan Tung Nguyen, Thi Van Oanh Kieu, Hai Yen Duong, Phuong Thao Pham, Thi Hue Hoang- Biochemistry (medical)
- Cell Biology
- Biochemistry
- General Medicine
Objective
This study aimed to assess the association of the neutrophil-to-lymphocyte ratio (NLR) with the occurrence of venous thromboembolism (VTE) and arterial thrombosis (AT).
Methods
This was a retrospective cross-sectional study including 585 medical records obtained from all consecutive patients who were suspected of having thrombosis.
Results
The AT group had a higher neutrophil count and NLR and a lower lymphocyte count than the non-thrombosis group. Receiver operating characteristic curve analysis showed the ability of the NLR to predict the presence of AT. The cut-off value for the NLR was 4.44. No distinction was found in the NLR between the VTE and non-thrombosis groups. Regression analysis showed that a high NLR was an independent factor related to the presence of AT. Patients with an NLR ≥ 4.44 had a higher risk of AT than those with an NLR < 4.44 (odds ratio = 2.015, 95% confidence interval: 1.180–3.443).
Conclusion
A high NLR may be considered a predictive factor for the occurrence of AT, but an association with the presence of VTE was not found.