DOI: 10.3390/md23010025 ISSN: 1660-3397

Bioactive Angucyclines/Angucyclinones Discovered from 1965 to 2023

Hai-Shan Liu, Hui-Ru Chen, Shan-Shan Huang, Zi-Hao Li, Chun-Ying Wang, Hua Zhang

Angucyclines/angucyclinones, a class of polyketides with diverse chemical structures, display various bioactivities including antibacterial or antifungal, anticancer, anti-neuroinflammatory, and anti-α-glucosidase activities. Marine and terrestrial microorganisms have made significant contributions to the discovery of bioactive angucyclines/angucyclinones. This review covers 283 bioactive angucyclines/angucyclinones discovered from 1965 to 2023, and the emphasis is on the biological origins, chemical structures, and biological activities of these interesting natural products.

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