Mustafa ÇİÇEK, Mehmet Kemal TÜMER, Alpgiray TURGUT

Can mecsina hemostopper, which has a cytotoxic effect on MCF-7 cells, be considered an anticarcinogenic agent due to its immunological properties?

  • Colloid and Surface Chemistry
  • Physical and Theoretical Chemistry
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Introduction: Mecsina is used as a hemostatic agent such as Ankaferd and Tranexamic acid. To struggle with breast cancer, which is a serious public health issue, new, effective, and less toxic therapeutic agents are needed. Hence, it is aimed to compare and evaluate the effects of Mecsina and Ankaferd, both of which contain natural biomolecules in their structure, and synthetic Tranexamic acid on MCF-7 cells. Material and Method: For this study, MCF-7 immortalized cell lines were commercially purchased. The cells, 5000 cells per flask for each different dose group, were distributed to the 9 groups (mecsina 1/1, mecsina 1/2, mecsina 1/10, mecsina 1/50, mecsina 1/100, mecsina 1/200, mecsina 1/500, distilled water-administered negative and control without any administration). Cytotoxicity, ELISA cytokine levels were evaluated, and flow cytometric analyzes were performed for each group using the XTT analysis method, after 24 hours of incubation. Findings: A significant difference was observed between different doses of drug administration groups of Mecsina Hemostopper hemostatic agent in MCF-7 cells (p

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