DOI: 10.1039/d4cb00008k ISSN: 2633-0679
Chemical synthesis of grafted cyclotides using a “plug and play” approach
Johannes Koehbach, Edin Muratspahić, Zakaria M Ahmed, Andrew M White, Nataša Tomašević, Thomas Durek, Richard J Clark, Christian W Gruber, David J Craik‘Plug and play’ grafting – a simple and convenient modular synthesis method to access complex cyclotide grafts and generate potent GPCR ligands is described.