DOI: 10.1039/d4ob00072b ISSN: 1477-0520

Chemoenzymatic total synthesis of rotigotine via IRED-catalyzed reductive amination

Dongyu Tang, Yaqing Ma, Jinping Bao, Shushan Gao, Shuli Man, Chengsen Cui
  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Biochemistry

An engineered imine reductase (IRED) was developed specifically for 2-tetralone substrate, and utilized in the total synthesis of rotigotine.

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