DOI: 10.1039/d4ob00072b ISSN: 1477-0520
Chemoenzymatic total synthesis of rotigotine via IRED-catalyzed reductive amination
Dongyu Tang, Yaqing Ma, Jinping Bao, Shushan Gao, Shuli Man, Chengsen Cui- Organic Chemistry
- Physical and Theoretical Chemistry
- Biochemistry
An engineered imine reductase (IRED) was developed specifically for 2-tetralone substrate, and utilized in the total synthesis of rotigotine.