Chemokine Receptor 4–Targeted PET/CT With 68Ga-Pentixather Detects More Lesions Than 68Ga-Pentixafor PET/CT in Multiple Myeloma

Abstract

An 83-year-old woman with newly diagnosed multiple myeloma (MM) was enrolled in our ⁶⁸Ga-pentixather and ⁶⁸Ga-pentixafor PET/CT trial for evaluation of tumor burden. ⁶⁸Ga-pentixather PET/CT detected more focal bone lesions, and the uptake levels of focal bone lesions on ⁶⁸Ga-pentixather PET/CT were higher than those on ⁶⁸Ga-pentixafor PET/CT. This suggests that ⁶⁸Ga-pentixather PET/CT may be an alternative imaging modality and more sensitive in detecting MM lesions than ⁶⁸Ga-pentixafor PET/CT.