DOI: 10.1039/d4md00076e ISSN: 2632-8682

Chiral hydroxymethyl-1H,3H-pyrrolo[1,2-c]thiazoles: the search for selective p53-activating agents for colorectal cancer therapy

Mees M. Hendrikx, Adelino M. R. Pereira, Ana B. Pereira, Carla S. C. Carvalho, João L. P. Ribeiro, Maria I. L. Soares, Lucília Saraiva, Teresa M. V. D. Pinho e Melo
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science
  • Pharmacology
  • Molecular Medicine
  • Biochemistry
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Structural modulation of a lead p53-activating anticancer molecule was performed, leading to the synthesis of new bioactive molecules. Activity against human colorectal cancer cells with different p53 status provided in-depth SAR data.

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