Circulating Serotypes & Genotypes of Dengue Virus in North India: an observational study
O Prakash, AK Verma, A Paliwal, F Abbas, A Srivastava, V Mishra, S Radera, A Jain- Infectious Diseases
- General Medicine
- Parasitology
ABSTRACT
Background & objectives:
This study reports observation on circulating serotypes & genotypes of Dengue Virus in North India.
Methods:
Serum samples were obtained from suspected cases of dengue referred to the virus diagnostic laboratory during 2014 to 2022. All samples were tested for anti-dengue virus IgM antibodies and NS1Ag by ELISA. NS1Ag positive samples were processed for serotyping & genotyping.
Results:
Total 41,476 dengue suspected cases were referred to the laboratory of which 12,292 (29.6%) tested positive. Anti-Dengue Virus IgM antibodies, NS1Ag, both IgM and NS1Ag, were positive in 7,007 (57.4%); 3,200 (26.0%) and 2,085 (16.0%) cases respectively. Total 762 strains were serotyped during 9 year period. DV1, DV2, DV3 and DV4 serotypes were found in 79 (10.37%), 506 (66.40%), 151 (19.82%) and 26 (3.41%) cases respectively. DV-1, DV-2 & DV-3 were in circulation through out. Total 105 strains were genotyped. Genotype IV of DV-1 serotype was circulating till 2014 which was later replaced by genotype V. A distinct seasonality with increase in number of cases in post monsoon period was seen.
Interpretation & conclusion:
DV-1, DV-2 & DV-3 were found to be in circulation in North India. Predominant serotype/genotype changed at times, but not at regular intervals.