Petra Černá, Cristobal Lopez‐Jimenez, Kenjiro Fukushima, Ko Nakashima, Taisuke Nakagawa, Fiona Adam, Anna Groth, Andrew Denning, Nicolas Israeliantz, Danièlle A. Gunn‐Moore

Clinicopathological findings, treatment, and outcome in 60 cats with gastrointestinal eosinophilic sclerosing fibroplasia

  • General Veterinary
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AbstractBackgroundGastrointestinal eosinophilic sclerosing fibroplasia (GESF) in cats presents as mass(es) associated with the gastrointestinal tract, mesentery, and abdominal lymph nodes.Hypothesis/ObjectivesTo report the clinicopathological findings, treatment, and outcome of cats with GESF.AnimalsSixty client‐owned cats diagnosed with GESF.MethodsRetrospective review of medical records of cats with histopathologically confirmed GESF.ResultsThe median age was 5.4 years (interquartile range [IQR], 3.3‐8.9.); 30% were Domestic Shorthairs and 12% were Domestic Longhair cats, with the most prevalent pedigree breeds being Ragdolls (25%), Exotic Shorthair (10%) and Persian (8%) cats. The median duration of clinical signs was 90 days (IQR, 17.5‐247.0); the most common clinical signs were weight loss (60%), hyporexia/anorexia (55%), chronic vomiting (37%), lethargy (35%) and chronic diarrhea (27%). Masses were located in the small intestine (32%), stomach (27%), ileocolic junction (15%), colon (10%), lymph node (8%) and mesentery (8%) and 15% of cats had >1 mass. Eosinophilia was present in 50% and hypoalbuminemia in 28% of cats. The mass was removed surgically in 37% of cases. Most cats (98%) were treated with corticosteroids. Survival was not statistically different between cats treated with surgical resection and cats treated with medical therapy alone, 88% of the cats were still alive at the time of writing.Conclusions and Clinical ImportanceGESF is an important differential diagnosis for abdominal masses in cats, and has a much better prognosis than previously reported.

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